diff --git a/changelog.d/12258.misc b/changelog.d/12258.misc
new file mode 100644
index 0000000000..80024c8e91
--- /dev/null
+++ b/changelog.d/12258.misc
@@ -0,0 +1 @@
+Compress metrics HTTP resource when enabled. Contributed by Nick @ Beeper.
diff --git a/synapse/app/homeserver.py b/synapse/app/homeserver.py
index e4dc04c0b4..ad2b7c9515 100644
--- a/synapse/app/homeserver.py
+++ b/synapse/app/homeserver.py
@@ -261,7 +261,10 @@ class SynapseHomeServer(HomeServer):
             resources[SERVER_KEY_V2_PREFIX] = KeyApiV2Resource(self)
 
         if name == "metrics" and self.config.metrics.enable_metrics:
-            resources[METRICS_PREFIX] = MetricsResource(RegistryProxy)
+            metrics_resource: Resource = MetricsResource(RegistryProxy)
+            if compress:
+                metrics_resource = gz_wrap(metrics_resource)
+            resources[METRICS_PREFIX] = metrics_resource
 
         if name == "replication":
             resources[REPLICATION_PREFIX] = ReplicationRestResource(self)