diff --git a/CHANGES.md b/CHANGES.md
index 8029a9d21c..ced1dcc0db 100644
--- a/CHANGES.md
+++ b/CHANGES.md
@@ -1,6 +1,21 @@
+Synapse 1.50.1 (2022-01-18)
+===========================
+
+This release fixes a bug in Synapse 1.50.0 that could prevent clients from being able to connect to Synapse if the `webclient` resource was enabled. Further details are available in [this issue](https://github.com/matrix-org/synapse/issues/11763).
+
+Bugfixes
+--------
+
+- Fix a bug introduced in Synapse 1.50.0rc1 that could cause Matrix clients to be unable to connect to Synapse instances with the `webclient` resource enabled. ([\#11764](https://github.com/matrix-org/synapse/issues/11764))
+
+
 Synapse 1.50.0 (2022-01-18)
 ===========================
 
+**This release contains a critical bug that may prevent clients from being able to connect. 
+As such, it is not recommended to upgrade to 1.50.0. Instead, please upgrade straight to
+to 1.50.1. Further details are available in [this issue](https://github.com/matrix-org/synapse/issues/11763).**
+
 Please note that we now only support Python 3.7+ and PostgreSQL 10+ (if applicable), because Python 3.6 and PostgreSQL 9.6 have reached end-of-life.
 
 No significant changes since 1.50.0rc2.
diff --git a/debian/changelog b/debian/changelog
index f1245cd3af..18983f5da6 100644
--- a/debian/changelog
+++ b/debian/changelog
@@ -1,3 +1,9 @@
+matrix-synapse-py3 (1.50.1) stable; urgency=medium
+
+  * New synapse release 1.50.1.
+
+ -- Synapse Packaging team <packages@matrix.org>  Tue, 18 Jan 2022 16:06:26 +0000
+
 matrix-synapse-py3 (1.50.0) stable; urgency=medium
 
   * New synapse release 1.50.0.
diff --git a/synapse/__init__.py b/synapse/__init__.py
index 201925e91d..5ec9f94174 100644
--- a/synapse/__init__.py
+++ b/synapse/__init__.py
@@ -47,7 +47,7 @@ try:
 except ImportError:
     pass
 
-__version__ = "1.50.0"
+__version__ = "1.50.1"
 
 if bool(os.environ.get("SYNAPSE_TEST_PATCH_LOG_CONTEXTS", False)):
     # We import here so that we don't have to install a bunch of deps when
diff --git a/synapse/app/homeserver.py b/synapse/app/homeserver.py
index 177ce040e8..dd76e07321 100644
--- a/synapse/app/homeserver.py
+++ b/synapse/app/homeserver.py
@@ -27,7 +27,6 @@ import synapse
 import synapse.config.logger
 from synapse import events
 from synapse.api.urls import (
-    CLIENT_API_PREFIX,
     FEDERATION_PREFIX,
     LEGACY_MEDIA_PREFIX,
     MEDIA_R0_PREFIX,
@@ -193,7 +192,13 @@ class SynapseHomeServer(HomeServer):
 
             resources.update(
                 {
-                    CLIENT_API_PREFIX: client_resource,
+                    "/_matrix/client/api/v1": client_resource,
+                    "/_matrix/client/r0": client_resource,
+                    "/_matrix/client/v1": client_resource,
+                    "/_matrix/client/v3": client_resource,
+                    "/_matrix/client/unstable": client_resource,
+                    "/_matrix/client/v2_alpha": client_resource,
+                    "/_matrix/client/versions": client_resource,
                     "/.well-known": well_known_resource(self),
                     "/_synapse/admin": AdminRestResource(self),
                     **build_synapse_client_resource_tree(self),