uBlock

Off the top of my head:

Cancels network requests early within the browser
Pattern-based filtering on the whole URL. Examples:
- Plain pattern: &act=ads_
- Wildcard-based pattern: /analytics.*/event?
- Regex-based pattern: /^https?:\/\/[a-z]{8,15}\.[a-z]{2,3}\/5\/\d{6,7}(?:\?_=\d+)?$/
Context information
- Example: $script,third-party,domain=imgbox.com
- Point-and-click to enable/disable blocking behavior on a per-site basis:
  - JavaScript
  - Large media elements
  - Remote fonts
  - Etc.
- You can see what specific network requests are made by what specific page, you can fully inform yourself of what specific pages/sites are causing your browser to do
  - Example: https://twitter.com/gorhill/status/934474012377444352
Ability to redirect to a neutered version of a resource
- Example: ||google-analytics.com/ga.js$script,redirect=google-analytics.com/ga.js
Cosmetic filtering, the manipulation of DOM elements in the browser
- Example: ##.AdHeader
Scriptlet injection filtering, the injection of JS scriptlets to modify the behavior of a page which is effective to defuse anti-content blockers
- Example: wallstreet-online.de##+js(nostif, userHasAdblocker)
HTML filtering (Tor Browser and Firefox only), the removal of DOM elements from a document before parsed by the browser
- Example: wetteronline.de##^script:has-text(runCount)
Ability to deal with unwanted popups
- Example: &link_type=offer$popup,third-party
Ability to remove tracking parameters from websites
- Example: ||wuzhuiso.com^$removeparam=src
You can easily (narrowly/broadly) override any filter from the filter lists through simple point-and-click operations to customize your filtering or to quickly fix sites broken as a result of overzealous filters

The main advantage of Pi-Hole is that it filters network traffic from all devices on your network, but filtering is blunt compared to what you can do through a browser extension.

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uBlock Origin - An efficient blocker for Chromium and Firefox. Fast and lean.